Prevention and cure of Type 1 diabetes in mice was achieved by a team of Stanford researchers by using a a preconditioning regimen together with a unique combination of blood stem cell and islet cell transplantation. This led to prevention and cure with improved immune tolerance, and without chronic immunosuppression or graft-versus-host disease
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Sclerostin plays a crucial role in bone formation but restrains abnormal bone growth in joints, which can worsen osteoarthritis. This paradox inspired the design of two short peptides with opposite functions — one restores bone in osteoporosis, while the other protects cartilage in osteoarthritis
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Russell’s viper venom show variations based on biogeography. So, antivenom efficacy is low for Russell’s viper in North India. Studies carried out in mice have demonstrated that two approved drugs were effective in countering systemic and lethal effects of the venom either individually or in combination from across India.
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FDA has said that the Mumbai-based Raptim Research has been “responsible for the creation of false in vitro study data”
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Three years after the interim data were posted as a preprint, Bharat Biotech and ICMR are yet to publish any
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If the Indian drug regulator greenlights it, a human clinical trial to test the safety and efficacy of a novel
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The third dose of vaccine is scheduled to be administered at 14 weeks of age, but children presented at a
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In animal studies, the FDA-approved deworming drug was able to significantly inhibit the tumour cells and improve the survival rate
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A new research challenges the dogma that toxicity caused by chemotherapy is due to the direct damaging effect of drugs
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The efficacy of the conjugated typhoid vaccine at the end of 4.3 years of median follow-up was 70·6% for children
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ICMR’s consensus policy statement on human challenge studies insists that payment should take into account the loss of wages, incidental
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In the randomised controlled trial involving household contacts of patients with pulmonary TB, nutritional support led to 39-48% reduction in TB disease in the intervention group
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Are human studies more challenging than clinical trials, and what are the benefits in a country where the burden of infectious diseases is high?
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