An integrated metabolic model combined with experimental studies using cell lines and mice model helped identify arginine metabolism as a key driver of disease-causing ability of Candida and the ALT1 enzyme as being crucial for the pathogen’s survival and virulence
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Sclerostin plays a crucial role in bone formation but restrains abnormal bone growth in joints, which can worsen osteoarthritis. This paradox inspired the design of two short peptides with opposite functions — one restores bone in osteoporosis, while the other protects cartilage in osteoarthritis
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CDRI researchers have used a specific fragment of a protein secreted by the parasitic worm liver fluke to protect the
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A molecule identified by IIT Roorkee researchers exhibits broadspectrum bactericidal activity against multidrug-resistant bacteria. The molecule was found to be
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IISc researchers have discovered the mechanism by which TB bacteria develop tolerance to TB drugs. They found a combination of
Read MoreIISER Pune researchers have identified novel drug targets to kill multidrug-resistant Staphylococcus aureus. They increased the small molecule’s ability to
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When used in combination with bedaquiline and linezolid, the newly approved pretomanid drug for MDR-TB and XDR-TB had an overall
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A novel compound isolated from a soil bacterium by IMTECH researchers shows promise in killing Gram-negative bacteria (Klebsiella pneumoniae and
Read MoreJNCASR researchers along with French counterparts have been able to fully restore neuron to neuron connections and long-term memory in
Read MoreAmit Singh from IISc explains how a protein (WhiB4) that condenses the DNA of TB-causing bacteria in response to
Read MoreIISc researchers have for the first time identified a protein (WhiB4) that condenses the DNA of TB-causing bacteria in response to
Read MoreScientists from AIIMS, THSTI and IIT Indore have successfully been able to inhibit the entry of TB bacteria into host cells
Read MoreA team of researchers from three institutions in India has used aptamer-based inhibitor that binds to the HupB protein found
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