April 1, 2026

Science Chronicle

A Science and Technology Blog

April 1, 2026

Science Chronicle

A Science and Technology Blog

Human challenge studies

Clinical trialHealthHuman challenge studiesResearch

Compensation to participants in human challenge studies should not incentivise risk-taking

ICMR’s consensus policy statement on human challenge studies insists that payment should take into account the loss of wages, incidental

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Clinical trialHealthHuman challenge studiesResearch

Are human challenge studies effective? 

Are human studies more challenging than clinical trials, and what are the benefits in a country where the burden of infectious diseases is high?

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Clinical trialHealthHuman challenge studies

ICMR takes the first step in Controlled Human Infection Studies

In the last 50 years, CHIS studies have been carried out with thousands to accelerate vaccine development against typhoid and cholera

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COVID-19Human challenge studiesResearchSARS-CoV-2

Human challenge study finds high viral shedding in asymptomatic people

The study first detected the virus in the throat and the nose two days before peak symptoms showed up

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Clinical trialCommunicable diseaseCoronavirusCOVID-19Human challenge studiesPublic HealthSARS-CoV-2Vaccines

Human challenge trials will help us design better treatments, vaccines than we can now: Gagandeep Kang

The world’s first human challenge trial for a vaccine against SARS-CoV-2 is set to begin in London in January. Human challenge trials for the SARS-CoV-2 virus have many challenges, including producing a strain that is less virulent, but Dr. Gagandeep Kang says such trials can provide information and help design better vaccines than we can do now with conventional trials.

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Clinical trialCoronavirusFDAHealthHuman challenge studiesNIHPublic HealthSARS-CoV-2VaccinesWorld Health Organisation

WHO backs COVID-19 vaccine trials that deliberately infect participants

In new guidelines issued on May 6, WHO has backed human challenge studies for COVID-19 vaccines on the ground that

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