Prevention and cure of Type 1 diabetes in mice was achieved by a team of Stanford researchers by using a a preconditioning regimen together with a unique combination of blood stem cell and islet cell transplantation. This led to prevention and cure with improved immune tolerance, and without chronic immunosuppression or graft-versus-host disease
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When the TB drug moxifloxacin was masked as a prodrug form, the prodrug’s permeability into the bacteria improved significantly. Once inside the bacteria, the prodrug is activated by an enzyme leading to the generation of the active drug moxifloxacin within the bacteria. This strategy significantly enhanced the lethality against TB persisters, thus effectively reducing the population of persisters
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Unlike many current leukaemia drugs that target only one pathway, a molecule designed by IACS researchers attacks two essential oncogenes at the same time, leaving cancer cells with no fallback options. As the molecule acts at the DNA-regulation level, it may also bypass some of the resistance mechanisms seen with protein-targeting inhibitors
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The IHCI study found that individuals aged 45-54 years had a higher risk of uncontrolled BP compared with those aged over 55 years. And compared with females, males had a higher risk of uncontrolled BP, and those with diabetes exhibited a higher risk. Also, individuals who were already on treatment at the time of registration had a higher risk of having uncontrolled BP
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The RAD52 protein is a coveted drug target for precision oncology because while it is largely dispensable in healthy human cells, the protein is essential for survival of cancer cells that are deficient in DNA repair function, such as those with defective BRCA1 or BRCA2 genes
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The study of over 4,800 Indian adolescents found 16.1% had subclinical hypothyroidism and 1.1% had clinical hypothyroidism. Subclinical and clinical hypothyroidism in adolescents were not linked to obesity but to dyslipidemia and altered levels of adiponectin, suggesting early metabolic disruptions even before visible changes in body weight
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Genetic variants can drastically change how certain enzymes work. While some people are fast metabolisers — they break down drugs too quickly before the medicine even has time to act — some others are slow metabolisers: their bodies process drugs too slowly, allowing the drugs to build up to toxic levels
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During 2018-2024, there were 3,955 cases of cVDPV polio globally, averaging 565 cases per year. As on September 17, 2025, 143 cVDPV cases have been reported this year. In 2023, five polio cases in east Afghanistan were in children who had received 16 to 28 OPV doses.
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Once seen mainly in old people who are heavy smokers, lung cancer is now increasingly striking young adults aged under 50 years who have never smoked. But outdated medical mindset often fails to suspect lung cancer in young people costing many young lives
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Cancer initiation and spread are governed as much by mechanical context as by genetics. The physics of the tissue plays an important role in both triggering tumour development in one tissue and not in another, and in determining whether cancer progresses
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A newly designed three-in-one nanosystem for cancer treatment is truly unique and multifunctional. It enhances radiation therapy by sensitising the cancer cells to radiation, delivers multiple drugs and on-demand drug delivery that gets triggered by radiation for chemotherapeutics at the tumour site, and improves the contrast of tumour for X-ray/CT imaging
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Why does TB therapy take six-nine months, and why do some Mycobacterium tuberculosis inside macrophages survive antibiotics better than others? Rigorous experiments have now revealed that macrophage’s own metabolism and the host cell where the bacteria live play a key role in shaping drug tolerance
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Although the majority of HPV-related cancers develop in mucosal tissues like the throat or cervix, the rare case of a 34-year-old woman with recurrent cutaneous squamous-cell carcinoma implies that some skin-based HPV types may also directly cause cancer in people with weakened immune systems
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