When the TB drug moxifloxacin was masked as a prodrug form, the prodrug’s permeability into the bacteria improved significantly. Once inside the bacteria, the prodrug is activated by an enzyme leading to the generation of the active drug moxifloxacin within the bacteria. This strategy significantly enhanced the lethality against TB persisters, thus effectively reducing the population of persisters
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India’s AMR surveillance network is primarily built on a few dozen tertiary-care hospitals. The problem is not the quality of data from these tertiary centres; it is the narrowness of the sample. A surveillance system built only on a few dozen largest hospitals cannot speak for the entire country
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Why does TB therapy take six-nine months, and why do some Mycobacterium tuberculosis inside macrophages survive antibiotics better than others? Rigorous experiments have now revealed that macrophage’s own metabolism and the host cell where the bacteria live play a key role in shaping drug tolerance
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Genomic surveillance reveals resistance among key pathogens like Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Vibrio cholerae is rising rapidly, with susceptibility to commonly used antibiotics often falling below 20%
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Rather than trying to develop even stronger chemotherapy drugs, our approach aims to make cancer cells more sensitive to existing treatments by blocking their defence mechanisms. In this case, blocking TLK1 protein’s activity weakens the ability of cancer cells to survive, making it easier to kill them
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Kerala imports at least 60% of broiler chicken, eggs and vegetables from neighbouring States, many of which have no AMR
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Since it takes weeks to know drug resistance through culture, drug-resistant studies of H. pylori are seldom carried out here; empirical treatment using
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A small study has found evidence of colistin-resistant bacteria in the gut. 77% of such bacteria were found to be
Read MoreThree cheap, filter-based kits developed by a multi-institutional team and an industry partner improves the sensitivity of LED fluorescence microscopy
Read MoreThe 443 cholera-causing Vibrio cholerae isolates isolated from patients from Kolkata and Delhi show very high drug resistance to 22
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A novel compound isolated from a soil bacterium by IMTECH researchers shows promise in killing Gram-negative bacteria (Klebsiella pneumoniae and
Read MoreDuring Kumbh Mela in 2015, microbial diversity dropped by nearly 37.5% while bacterial load increased by about 130-fold at five
Read MoreAbdul Ghafur explains how the team deciphered the mechanism by which Klebsiella bacteria develop resistance to colistin, a last-line antibiotic. Mutations
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