A newly designed three-in-one nanosystem for cancer treatment is truly unique and multifunctional. It enhances radiation therapy by sensitising the cancer cells to radiation, delivers multiple drugs and on-demand drug delivery that gets triggered by radiation for chemotherapeutics at the tumour site, and improves the contrast of tumour for X-ray/CT imaging
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Rather than trying to develop even stronger chemotherapy drugs, our approach aims to make cancer cells more sensitive to existing treatments by blocking their defence mechanisms. In this case, blocking TLK1 protein’s activity weakens the ability of cancer cells to survive, making it easier to kill them
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Seventeen of 23 individuals exposed to chemotherapy had far more genetic mutations than could be explained by normal aging. Even more revealing was the discovery of eight unique mutational signatures that were found only in the chemotherapy group. While some of these fingerprints matched the known damage profiles of certain chemo drugs, four of them were entirely new to science, uncovering previously unknown ways these treatments can alter our DNA
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