When the TB drug moxifloxacin was masked as a prodrug form, the prodrug’s permeability into the bacteria improved significantly. Once inside the bacteria, the prodrug is activated by an enzyme leading to the generation of the active drug moxifloxacin within the bacteria. This strategy significantly enhanced the lethality against TB persisters, thus effectively reducing the population of persisters
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An AI tool developed by IIT Madras has made discovery of highly safe, effective drug analogues easily possible. In the case of the FDA-approved cancer drug Sorafenib, starting from its original structure, PURE produced hundreds of thousands of possible analogues, and then narrowed them down using basic drug-likeness filters. A manageable group of candidates that were selected exhibited docking scores comparable to, and in some cases, superior to those of Sorafenib
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Why does TB therapy take six-nine months, and why do some Mycobacterium tuberculosis inside macrophages survive antibiotics better than others? Rigorous experiments have now revealed that macrophage’s own metabolism and the host cell where the bacteria live play a key role in shaping drug tolerance
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FDA has said that the Mumbai-based Raptim Research has been “responsible for the creation of false in vitro study data”
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The paper published in the International Journal of Antimicrobial Agents was withdrawn because of concerns about the ethical approval for the research.
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Breakdown of the mucus barrier, which separates the intestinal epithelium from the microbiota, is a hallmark of inflammatory bowel diseases
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With less than two years left to achieve the ambitious goal set by Prime Minister Narendra Modi in 2018 to
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On October 1, the Health Ministry issued a press release for the second time in five days stating that “media reports claiming
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TB drug shortage began last year when Rifampicin — a medicine used for treating drug-sensitive TB — was not available
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In 1995, Tamil Nadu pioneered the centralised procurement and distribution of drugs and medicines to government hospitals across the State.
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Though the Central TB Division has not supplied 3HP drugs to States since its roll-out in March, Tamil Nadu and
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While drug supply from Centre was adequate during the pandemic, it has not kept pace after reporting of cases reached
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Currently, the Patents Act explicitly permits anyone to file a pre-grant opposition. But as per the draft patent amendment rules,
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