April 5, 2026

Science Chronicle

A Science and Technology Blog

April 5, 2026

Science Chronicle

A Science and Technology Blog

Drug safety

ChildrenCough syrupDiethylene glycol (DEG)Drug safetyFixed-dose combinations

Cough Syrups: How Irrational Fixed-Dose Combinations Can Turn Fatal

Cough syrups containing a mixture of antitussives, antihistamines, decongestants and expectorants may appear logical — one drug to dry secretions, another to suppress cough, a third to open nasal passages. But the underlying flaw is that these ingredients often work in opposing ways or have overlapping side effects

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ChildrenCough syrupDiethylene glycol (DEG)Drug companiesDrug safety

Poison in cough syrup bottles: The never-ending saga of DEG-related deaths

As long as protecting the reputation and interests of the Indian pharmaceutical industry is the top priority, it is unlikely that there will be any meaningful reforms to prevent future tragedies caused by DEG. The bid to cover up, distract and obfuscate, as seen in the last few days, serves as valuable pointers

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Drug safetyFixed dose combination drugsGeneric medicines

Why is irrational use of monteleukast as a combination drug continuing despite serious adverse effects?

Most antihistamines are sold as generics and are inexpensive. On the other hand, irrational combinations with montelukast sell at two-four times the cost of an antihistamine alone. The drug combinations are nothing but a sinister way to profiteer from common conditions. The proof: sales of montelukast as a standalone drug dropped 14%, while sales of combinations increased by 25% in 2023-24, with close to 200 registered brands selling combinations

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Drug companiesDrug safetyDrugsMedicinePharmaceutical companies

Indian pharma products exported to other countries fail the safety test, cause deaths

India can continue to be the pharmacy of the global south only if the regulator begins to behave like a watchdog to ensure drug safety, and not as a facilitator for the pharma industry

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