Unlike many current leukaemia drugs that target only one pathway, a molecule designed by IACS researchers attacks two essential oncogenes at the same time, leaving cancer cells with no fallback options. As the molecule acts at the DNA-regulation level, it may also bypass some of the resistance mechanisms seen with protein-targeting inhibitors
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The RAD52 protein is a coveted drug target for precision oncology because while it is largely dispensable in healthy human cells, the protein is essential for survival of cancer cells that are deficient in DNA repair function, such as those with defective BRCA1 or BRCA2 genes
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Genetic variants can drastically change how certain enzymes work. While some people are fast metabolisers — they break down drugs too quickly before the medicine even has time to act — some others are slow metabolisers: their bodies process drugs too slowly, allowing the drugs to build up to toxic levels
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Once seen mainly in old people who are heavy smokers, lung cancer is now increasingly striking young adults aged under 50 years who have never smoked. But outdated medical mindset often fails to suspect lung cancer in young people costing many young lives
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Cancer initiation and spread are governed as much by mechanical context as by genetics. The physics of the tissue plays an important role in both triggering tumour development in one tissue and not in another, and in determining whether cancer progresses
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A newly designed three-in-one nanosystem for cancer treatment is truly unique and multifunctional. It enhances radiation therapy by sensitising the cancer cells to radiation, delivers multiple drugs and on-demand drug delivery that gets triggered by radiation for chemotherapeutics at the tumour site, and improves the contrast of tumour for X-ray/CT imaging
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Although the majority of HPV-related cancers develop in mucosal tissues like the throat or cervix, the rare case of a 34-year-old woman with recurrent cutaneous squamous-cell carcinoma implies that some skin-based HPV types may also directly cause cancer in people with weakened immune systems
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Knowing our genetic risks means rewriting what was once seen as destiny. From uncertainty, we are moving toward awareness and prevention, and turning generations of loss into a future of hope
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A systematic review and meta-analysis found that women with metabolic syndrome are at an increased risk of gynaecological cancers, regardless of the study design, type of gynaecological cancers, and definition of metabolic syndrome
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A recent study has shown that a simple blood test can detect traces of cancer more than three years before it is clinically diagnosed. This is more than early detection. But screening tests will need to be 50 times more sensitive to reliably detect cancer this early
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Mandatory reporting would highlight which cancers are surging and where, enabling targeted campaigns — from anti-tobacco drives to HPV vaccination, and early screening in high-incidence areas. Several States have already made cancer notifiable, and their experiences offer valuable lessons
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An AI-powered, lightweight, diagnostic, web-based App — CerviSpectraDiag — developed by researchers from IIT Kharagpur and KIIT University for early detection of cervical cancer has an accuracy of 84.73%. It offers diagnosis in near real time while maintaining privacy and data security as processing of spectral data of cervical tissue happens at the device level
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Liquid biopsy offers a suite of benefits that are hard to match with tissue sampling, such as minimal invasiveness, repeatability, being more comprehensive, faster turnaround time, and cost-effectiveness
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