Animal studies

December 12, 2025 M. Balasubramanyam

Transplantation of Blood Stem Cells and Islet Cells Prevents, Cures Type 1 Diabetes in Mice

Prevention and cure of Type 1 diabetes in mice was achieved by a team of Stanford researchers by using a a preconditioning regimen together with a unique combination of blood stem cell and islet cell transplantation. This led to prevention and cure with improved immune tolerance, and without chronic immunosuppression or graft-versus-host disease

Animal studies Drug discovery Osteoarthritis Osteoporosis

September 10, 2025 Naibedya Chattopadhyay

One Protein, Two Cures: Harnessing Sclerostin’s Dual Nature to Tackle Osteoporosis, Osteoarthritis

Sclerostin plays a crucial role in bone formation but restrains abnormal bone growth in joints, which can worsen osteoarthritis. This paradox inspired the design of two short peptides with opposite functions — one restores bone in osteoporosis, while the other protects cartilage in osteoarthritis

Science Chronicle

Science Chronicle

Transplantation of Blood Stem Cells and Islet Cells Prevents, Cures Type 1 Diabetes in Mice

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One Protein, Two Cures: Harnessing Sclerostin’s Dual Nature to Tackle Osteoporosis, Osteoarthritis

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