Trojan Horse Strategy: How A Prodrug For Moxifloxacin Kills TB Persisters
When the TB drug moxifloxacin was masked as a prodrug form, the prodrug’s permeability into the bacteria improved significantly. Once inside the bacteria, the prodrug is activated by an enzyme leading to the generation of the active drug moxifloxacin within the bacteria. This strategy significantly enhanced the lethality against TB persisters, thus effectively reducing the population of persisters
Read More