Inseparable Connections: How the Loss Of A Single Gene In Fruit Flies, Humans Disrupts Brain Development, Causes Microcephaly
The loss of the Inseparable gene leads to premature differentiation of neural stem cells into neurons and cytokinesis failure. These cells attempt to divide but fail to maintain internal order. As a result, these defects leave the developing brain depleted of healthy progenitors, resulting in an abnormally small brain — microcephaly
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